MaCuMBA (2012-2016)

Marine microorganisms: Cultivation methods for improving their biotechnological applications.

Macumba was a European FP7 collaborative project (FP7-KBBE 311975)

  • Period: August 2012 – July 2016 (48 months)
  • Consortium: 22 partners from 11 countries
  • Coordinator: Stichting Koninklijk Netherlands Instituut voor Zeeonderzoek (NIOZ), The Netherlands

Marine microorganisms form an almost untapped resource of biotechnological potential. However, its use is hindered by the low success rate of isolation of novel microorganisms and often by poor growth efficiency. Hence, the vast majority of marine microorganisms has not been cultivated and is often considered as unculturable. MaCuMBA aims at improving the isolation rate and growth efficiency of marine microorganisms from conventional and extreme habitats, by applying innovative methods, and the use of automated high throughput procedures.

The approaches include the co-cultivation of interdependent microorganisms, as well as gradient cultures and other methods mimicking the natural environment, and the exploitation of cell-to-cell communication. Signalling molecules produced by microorganisms may be necessary for stimulating growth of the same or other species, or may prevent their growth. Signalling molecules also represent an interesting and marketable product.


Chloropicophyceae, a new class of picophytoplanktonic prasinophytes

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Diversity and oceanic distribution of prasinophytes clade VII, the dominant group of green algae in oceanic waters

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Improvement of phytoplankton culture isolation using single cell sorting by flow cytometry

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Diversity and oceanic distribution of the Parmales (Bolidophyceae), a picoplanktonic group closely related to diatoms

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Photosynthetic pigments of oceanic Chlorophyta belonging to prasinophytes clade VII

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Pseudo-nitzschia arctica sp. nov., a new cold-water cryptic Pseudo-nitzschia species within the P. pseudodelicatissima complex

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PhytoREF: a reference database of the plastidial 16S rRNA gene of photosynthetic eukaryotes with curated taxonomy

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Diversity of cultured photosynthetic flagellates in the North East Pacific and Arctic Oceans in summer

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